Society of Cutaneous Oncology Journal Club

November 8^th 2024

Previous November JC Topics

SoCO JC Timeline

JoCO Perspectives on the Science

Pre-Journal Club Questions

REDCap Survey

https://redcap.link/y4husghu

Role

Melanoma Experience

Advanced Melanoma Experience

Case One

Case Two

Propensity Score Experience

Comfort

Introduction - David

Objective

• The objective of this adjusted ITC was to compare the efficacy and safety of NIVO + RELA and NIVO + IPI as first-line treatments for patients with advanced melanoma using individual patient-level data from RELATIVITY-047 and CheckMate 067

Methods

• Data were analyzed in a manner to best align median and minimum follow-ups between the 2 trials
• Outcomes for RELATIVITY-047 were analyzed using a database lock of Oct 2023, with a median follow-up of 34 months (minimum follow-up, 33 months)
• Outcomes for CheckMate 067 were analyzed using a database lock of May 2024 (minimum follow-up, 10 years); however, to emulate RELATIVITY-047, the CheckMate 067 follow-up was truncated to April 2017, providing a median follow-up of 37 months (minimum follow-up, 36 months)

Methods

• Endpoints were selected based on data availability from both trials and included PFS, confirmed ORR, DOR, and MSS, all assessed per investigator, to allow comparability in endpoints between the 2 trials, as well as OS and TRAEs
• ITC was done using IPTW

Isaac

Sonia

Karam

Ross

Kevin

Ade

Jenny

Discussion - Don

REDCap Survey

https://redcap.link/wcp83ak8

Practice Changing