Journal of Cutaneous Oncology
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An open-access, peer-reviewed journal dedicated to the advancement of research and education in cutaneous oncology.
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Society of Cutaneous Oncology

Current Issue

Current Issue

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Perspectives on the Science

Evolving Standards for Resected High-Risk CSCC: Integrating Insights from C-POST and KEYNOTE-630

This perspective summarizes a multidisciplinary discussion of the C-POST trial, which demonstrated improved disease-free survival with adjuvant cemiplimab in patients with resected high-risk cutaneous squamous cell carcinoma (CSCC). Participants reflected on evolving practice patterns and considered the contrasting futility outcome of adjuvant pembrolizumab in the KEYNOTE-630 study. To help explore potential reasons for these divergent results, this piece incorporates reconstructed survival data—estimates derived from published Kaplan-Meier curves in the absence of individual patient data. The discussion underscores both the enthusiasm and the remaining uncertainty surrounding adjuvant immunotherapy in CSCC.

David Michael Miller, MD, PhD, Vishal Anil Patel, MD, Vernon Keith Sondak, MD, Vatche Tchekmedyian, MD, Ross David Merkin, MD, Isaac Brownell, MD, PhD, Reed E. Drews, MD, Sameer Gupta MD, Nikhil I. Khushalani, MD, Paul T. Nghiem, MD, PhD, Howard Lane Kaufman MD, Kevin Scott Emerick MD
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