Current Issue

Current Issue

Articles

Perspectives on the Science

Dual Checkpoint Blockade in MCC: Lessons from CheckMate 358 and the Questions That Remain

A multidisciplinary summary and perspective on the CheckMate 358 trial in advanced Merkel cell carcinoma, exploring the role of dual checkpoint blockade, challenges of trial interpretation, real-world practice patterns, and evolving views on therapeutic intent and long-term outcomes.

David Michael Miller, MD, PhD, Sunandana Chandra MD, Isaac Brownell MD, PhD, Paul T. Nghiem MD, PhD

The Evolving Role of ctDNA in Merkel Cell Carcinoma: Challenges and Opportunities

This perspective discusses the evolving role of circulating tumor DNA (ctDNA) in the management of Merkel Cell Carcinoma, highlighting findings from a recent multicenter study and insights from a multi-institutional Journal Club. Key opportunities and challenges related to ctDNA’s use in surveillance and treatment decision-making are explored.

David Michael Miller, MD, PhD, Vernon Keith Sondak MD, Sunandana Chandra MD, Kenneth Y Tsai MD, PhD, Howard Lane Kaufman MD, Sameer Gupta MD, Isaac Brownell MD, PhD, Yoshine Saito, Ann W. Silk MD, Manisha Thakuria MD, Paul Nghiem MD, PhD

Comparing First-Line Immunotherapy in Advanced Melanoma: No Clear Winner?

In this Perspective on Science piece, we reflect on the indirect treatment comparison analysis between RELATIVITY-047 and CheckMate 067 trial data.

Yoshine Saito, David Michael Miller MD, PhD, Isaac Brownell MD, PhD