Perspectives on the Science

Perspectives on the Science

Overview

In “Perspectives on the Science”, we provide commentary on a publication reviewed in our multi-institutional SoCO Journal Club. The comments in this article represent the views of the authors of this Perspectives on the Science piece. It does not represent views of any other members of SoCO or the affiliated institutions.

Volume 3, Issue 1

Dual Checkpoint Blockade in Merkel Cell Carcinoma: Lessons from CheckMate 358 and the Questions That Remain

A multidisciplinary summary and perspective on the CheckMate 358 trial in advanced Merkel cell carcinoma, exploring the role of dual checkpoint blockade, challenges of trial interpretation, real-world practice patterns, and evolving views on therapeutic intent and long-term outcomes.

David Michael Miller, MD, PhD, Vernon Keith Sondak MD, Sunandana Chandra MD, Vatche Tchekmedyian MD, Vishal Anil Patel MD, Adewole S. Adamson MD, MPP, Isaac Brownell MD, PhD, Reed E. Drews MD, Shailender Bhatia MD, Paul T. Nghiem MD, PhD

The Evolving Role of ctDNA in Merkel Cell Carcinoma: Challenges and Opportunities

This perspective discusses the evolving role of circulating tumor DNA (ctDNA) in the management of Merkel Cell Carcinoma, highlighting findings from a recent multicenter study and insights from a multi-institutional Journal Club. Key opportunities and challenges related to ctDNA’s use in surveillance and treatment decision-making are explored.

David Michael Miller, MD, PhD, Vernon Keith Sondak MD, Sunandana Chandra MD, Kenneth Y Tsai MD, PhD, Howard Lane Kaufman MD, Sameer Gupta MD, Isaac Brownell MD, PhD, Yoshine Saito, Ann W. Silk MD, Manisha Thakuria MD, Paul Nghiem MD, PhD

Comparing First-Line Immunotherapy in Advanced Melanoma: No Clear Winner?

In this Perspective on Science piece, we reflect on the indirect treatment comparison analysis between RELATIVITY-047 and CheckMate 067 trial data.

Yoshine Saito, David Michael Miller MD, PhD, Isaac Brownell MD, PhD

Volume 2, Issue 1

Perspectives on Medical Aid in Dying: A Multifaceted Ethical Discussion

In this Perspectives on the Science piece, we reflect on the complex ethical considerations surrounding Medical Aid in Dying, integrating insights from a recent multi-institutional journal club discussion.

David Michael Miller MD, PhD, Isaac Brownell MD, PhD, Vatche Tchekmedyian MD, Vishal Anil Patel MD, Howard Lane Kaufman MD, Kevin Scott Emerick MD

Imaging Surveillance for Stage III Melanoma: Should We Be Stalkers or Casual Observers?

In this Perspectives on the Science piece, we reflect on the role of surveillance imaging for patients with high-risk melanoma.

Kevin Scott Emerick MD, David Michael Miller MD, PhD

A Closer Look: Evaluating Mohs Surgery’s Role in the Treatment of Invasive Melanoma of the Head and Neck

In this Perspectives on the Science piece, we reflect on the implications of the recently conducted multicenter study on the treatment of invasive head and neck melanoma using Mohs micrographic surgery.

Lauren Ching, Jennifer Strong, Truelian Lee, Howard Lane Kaufman MD, Kevin Scott Emerick MD, Emily Y. Kim, Vishal Anil Patel MD, Isaac Brownell MD, PhD, Kritika Singh, Victor A. Neel MD, PhD, David Michael Miller MD, PhD, Sameer Gupta MD

Volume 1, Issue 2

Adjuvant anti-PD-1 for Merkel Cell Carcinoma: Ready for the Clinic?

In this Perspectives on the Science piece we reflect on the recently published ADMEC-O trial.

David Michael Miller MD, PhD, Jennifer Strong, Kevin Scott Emerick MD, Sameer Gupta MD, Ann W Silk MD, Isaac Brownell MD, PhD

To Screen or Not To Screen, That is the Question

In this Perspectives on the Science piece we reflect on the impact of the recent USPSTF recommendation statement on skin cancer screening.

Truelian Lee, David Michael Miller MD, PhD, Howard Lane Kaufman MD, Kevin Scott Emerick MD, Sameer Gupta MD, Laura K Ferris MD, PhD

Volume 1, Issue 1

Immunotherapy and Cardiovascular Health - A Cause for Concern?

In this Perspectives on the Science piece we reflect on the impact of ‘Association Between Immune Checkpoint Inhibitors With Cardiovascular Events and Atherosclerotic Plaque’ by Drobni et al.

Miller, David M., Ferris, Laura K., Gupta, Sameer, Brownell, Isaac, Shalhout, Sophia Z.

Perioperative Immunotherapy for High-Risk Resectable Melanoma - A New Standard?

In this Perspectives on the Science piece we reflect on the impact of the recently published SWOG S1801 trial.

Serena Vilasi, David Michael Miller MD, PhD, Howard Lane Kaufman MD, Kevin Scott Emerick, Sophia Zaki Shalhout PhD, Emily Y Kim, Vishal Anil Patel MD, Khalid Garmen, Sameer Gupta MD, Isaac Brownel MD, PhD

Skin Cancer Chemoprevention for Transplant Recipients - The Search Continues

In this Perspectives on the Science piece, we reflect on the impact of the recently published ONTRANS trial.

Howard Lane Kaufman MD, Vishal Anil Patel MD, Sophia Zaki Shalhout PhD, Sameer Gupta MD, Sonia Cohen MD, PhD, Isaac Brownell MD, PhD, David Michael Miller MD, PhD

Lacking Overall IMspiration for Triplet Therapy in Melanoma? A Review of the Interim Analysis of IMspire150.

In this Perspectives on the Science piece, we reflect on the impact of the recently published article by Ascierto et al. in Lancet Oncology that provides interim results from IMspire150.

David Michael Miller MD, PhD, Kevin Scott Emerick MD, Vishal Anil Patel MD, Sonia Cohen MD, PhD, Isaac Brownell MD, PhD, Donald P. Lawrence MD

Tumor-Infiltrating Lymphocyte Therapy for Advanced Melanoma: Ready for Prime Time?

In this Perspectives on the Science piece, we reflect on the impact of the recently published article “Tumor-Infiltrating Lymphocyte Therapy or Ipilimumab in Advanced Melanoma”.

Emily Y Kim, Sophia Zaki Shalhout PhD, Howard Lane Kaufman MD, Kevin Scott Emerick MD, Vishal Anil Patel MD, Khalid Garmen MD, PhD, Isaac Brownell MD, PhD, David Michael Miller MD, PhD

Neoadjuvant Nivo/Rela for Resectable Melanoma

In this Perspectives on the Science piece we reflect on the impact of the recently published article Neoadjuvant relatlimab and nivolumab in resectable melanoma.

David Michael Miller MD, PhD, Howard Lane Kaufman, Kevin Scott Emerick MD, Justine V. Cohen MD, Emily Y. Kim, Sophia Zaki Shalhout PhD.

Ipi/Nivo for Advanced MCC

In this Perspectives on the Science piece we reflect on the impact of the recently published article “Combined Nivolumab and Ipilimumab with or without Stereotactic Body Radiation Therapy for Advanced Merkel cell carcinoma - A Randomised, Open Label, Phase 2 Trial”.

Shalhout, Sophia Z., Cohen, Justine V., Garmen, Khalid, Kim, Emily Y., Cohen, Sonia, Miller, David M.

Neoadjuvant ICI for Resectable CSCC

In this Perspectives on the Science piece we reflect on the impact of the recently published article “Neoadjuvant Cemiplimab for Stage II to IV Cutaneous Squamous-Cell Carcinoma”.

Miller, David M., Patel, Vishal A., Cohen, Justine V., Garmen, Khalid, Shalhout, Sophia Z.